Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.

Genome Biol · 2020 · PMC7281935 · PMID 32513296

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Examining the sequence within and around each gene (± 100 kbp), and using a cut-off of GERP > 2 as a definition of a constrained site, we identified a highly significant enrichment of NCCMs in the neighborhood of the 78 key GBM genes with 26 genes being enriched for NCCMs (> 1 NCCMs/100 kbp).

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