Surprisingly, despite the parasitological protection observed in the spleen in SIR-treated hamsters, we found a decreasing trend in IFN-γ production in the same tissue, suggesting that the mediated protection in our model may not be due to the expected SIR effect (increase of IFN-γ production), or at least we could not detect it by analyzing the whole spleen at five weeks post-infection.
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Sirolimus enhances the protection achieved by a DNA vaccine against Leishmania infantum.
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