Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation.

Front Physiol · 2020 · PMC7283609 · PMID 32581830

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highly significantno p-value reported

Fibers incorporated with the two mutations exhibited highly significant different and opposite response of calcium sensitivity to lengthening, i.e., calcium sensitization for the HCM and calcium desensitization for the DCM mutation.

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