In patients with breast cancer, the SHBG expression levels revealed a decreasing trend after the age of 50, which was different compared with the healthy females.
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Serum concentration of sex hormone-binding globulin in healthy volunteers and patients with breast cancer stratified by sex and age.
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SHBG expression levels were compared by age in patients with breast cancer regardless of cancer state, and these levels exhibited a decreasing trend which revealed an increasing trend in healthy females ( Fig. 4A ).