Barely Significant
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Toxicity and efficacy of Gamma Knife radiosurgery for brain metastases in melanoma patients treated with immunotherapy or targeted therapy-A retrospective cohort study.

Cancer Med · 2020 · PMC7286469 · PMID 32249551

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a nonsignificant trendno p-value reported
We did observe a nonsignificant trend of more intralesional hemorrhages after GKRS in patients treated with anti‐PD1 alone as well as a higher rate of radiation reaction/necrosis in patients treated with a combination of anti‐CTLA‐4/PD1 (Table 2 ).

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