Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells.

PLoS One · 2020 · PMC7289443 · PMID 32525891

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Loss of STAT6 appears to be associated with trastuzumab resistance because we observed a highly significant decrease in STAT6 expression in clones of BT474 that were conditioned to be resistant to trastuzumab. i.e., STAT6 expression decreased after the cells acquired resistance to trastuzumab.

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