Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia.

NPM1, IDH2 R172 , and TP53 mutations are predictive of survival in elderly AML patients Clinical factors significantly predictive for poor OS in univariate Cox analysis in intensively treated patients were male gender, high lactate dehydrogenase, poor WHO performance status, and high ELN risk, while low hemoglobin and AHD–AML showed borderline significance ( P -values 0.08 and 0.06, respectively) (Supplementary Table S3 ).

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