IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer.

Analysis of the survival effect of IGFBP-3 expression in all cancers identified its highly significant effect on survival in glioma (FDR = 1.51∙10 −32 (Hazard Ratio, HR = 4.39)) ( Figure 5 A and Figure 6 A).

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Consequent analysis of the survival effect of IGFBP-3 and TMEM219 in clinical subgroups of the breast cancer cohort revealed that clinical subgroup annotated as “histological type-Infiltrating Lobular Carcinoma” show marginally significant association of IGFBP-3 (FDR = 2.01∙10 −1 (HR = 0.36)) and TMEM219 ((3.96∙10 −2 (HR = 0.25)) with the survival outcome ( Figure 10 B,C).

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