Gene expression dynamics are a proxy for selective pressures on alternatively polyadenylated isoforms.

We further analyzed three extensive embryonic mRNA, protein and APA datasets from Xenopus laevis ( 45 , 46 ) and observed similarly highly significant trends for this vertebrate species (Figure 5C ; P < 0 −6 , Mann–Whitney test; N = 1953, 996 for HCI and LCI, respectively).

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