highly significantp < 1.08 × 10 −7
Interestingly, mass spectrometry analysis revealed that differentiation of Nsd1 -expressing Nsd1 −/− erythroblasts was associated with a highly significant reduction (logFC = −1.96; p < 1.08 × 10 −7 ) of the transcriptional repressor protein SKI previously proposed to interact with and inhibit GATA1 activation, most likely in cooperation with the nuclear co-repressor (NCoR) complex (Fig. 8g, h , Supplementary Fig. 6d ) 43 , 44 .