Elevation of intracranial pressure affects the relationship between hemoglobin concentration and neuronal activation in human somatosensory cortex.

Results with p < .05 were considered statistically significant, results with p < .0005 were considered highly significant. 2.8.4 Functional imaging data While the analysis explained in Section 2.8.3 is suitable to assess the breathing maneuvers' effect on the cortical Hb time courses during MNS in a predefined region of interest, it does not consider the image contrast induced by vascular changes evoked by MNS.

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When subtracting oxy‐Hb and deoxy‐Hb time courses during escalating breathing maneuvers without MNS from corresponding time courses with MNS, the functional hyperoxygenation response is diminished to a slight trend (BH) or vanishes altogether (V15 and V35).

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While we were able to recover functional oxygen changes in the motor cortex by subtracting responses to BH without responses with finger tapping (Knauth et al., 2017 ), only a weak trend toward functional oxygenation changes remains when applying BH to MNS and SI.

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