a decreasing trendP =0.002
CK Total Activity In comparison with NHBx hearts, median total CK activity was significantly lower both in SevAS-rEF (by 43%, post hoc one-sided P =0.016) and SevAS-pEF (by 35%, post hoc one-sided P =0.028), resulting in a decreasing trend in median values ( P =0.002; Figure 4 A, Table 2 ).