Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults.

We also considered CpG sites differentially methylated in previous EWAS on individuals exposed to adverse life events, on clinical ADHD or on ADHD symptoms and found that CpG sites previously associated with current vs never smoking and with maternal smoking showed a highly significant enrichment of signal for adult ADHD ( P Bootstrap = 9.03E−18 and P Bootstrap = 4.62E−14, respectively) (Supplementary Table 1 [excel file]).

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