marginally significantp = 0.082
Tobacco smoking was significantly associated with reduced recurrence-free survival (50.2% versus 100% for never smokers; log-rank p = 0.045), while HPV-status association with increased recurrence-free survival was marginally significant (75.5% for HPV-positive versus 48.8% for HPV-negative; log-rank p = 0.082) (Supplementary Fig. 1A,B ).