Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (<i>WT1</i>) gene.

Proc Natl Acad Sci U S A · 2020 · PMC7306989 · PMID 32493750

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highly significantP < 1.8 × 10 −4actually significant

Fisher’s Exact test (two-tailed) on the frequency of LOF and nonsynonymous variants associated with 46,XX DSD observed in our cohort, compared with rare (Minor Allelic Frequency [MAF] < 0.01%) LOF and nonsynonymous variants in the WT1 gene from control individuals, shows a highly significant enrichment of these WT1 variants in the patient cohort ( P < 1.8 × 10 −4 ).

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Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (&lt;i&gt;WT1&lt;/i&gt;) gene.

The sentences

Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (<i>WT1</i>) gene.