Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.

Ndst1 mutant mice exhibited 38% decrease in Ptch1 expression compared to control mice (8.6 ± 0.7 vs 13.8 ± 3.0 dots/cells in mutant and control mice respectively, n = 5 mice/group) although it did not quite reach significance (p=0.07) ( Figure 7E ).

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p<0.05 was considered significant and p<0.01 highly significant.

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