IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis.

7 , 8 The mechanisms that may be involved in Ps and AD itch are complex and multifactorial, 9 however, the role of inflammation is likely to be significant since several inflammatory mediators elevated in both conditions are known to cause itch and anti-inflammatory treatments can reduce inflammatory signs as well as itch. 8 , 10 Interleukins are cytokines which play key roles in pro-inflammatory and anti-inflammatory signaling pathways.

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