Novel Comprehensive Bioinformatics Approaches to Determine the Molecular Genetic Susceptibility Profile of Moderate and Severe Asthma.

PPI analysis revealed that some genes have a highly significant association with the different types of asthma; these include: PER2, SLAMF7, SOD2, BCL3, TLL1, SIGLEC8, and NAV2 for moderate asthma ( Figure 4 A), SLCO1B3, DNAJC1, WNK4, TPO, TMEM74B, TGM7, and PLAC4 for severe asthma ( Figure 4 C), and WNK4, SLCO1B3, KCNN4, CPXM1, SYT13, KRT73, SEMA3E, CD2AP, IL20RB, and NAT8B for moderate-to-severe asthma ( Figure 4 F).

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