trending toward significanceP = 0.06
(Table S1 ) When we analyzed sNfL levels after a clinical relapse by location, only recent spinal cord relapses were associated with a significant percentage increase in sNfL (estimated increase: 23.4%, 95% CI: 3%–47.7%, P = 0.03); recent relapses localized to the brainstem and cerebellum were associated with a percentage increase in sNfL trending toward significance (estimated increase: 28.4%, 95% CI: –1%–64.9%, P = 0.06).