QbD based development of HPLC method for simultaneous quantification of Telmisartan and Hydrochlorothiazide impurities in tablets dosage form.

Pract Lab Med · 2020 · PMC7322094 · PMID 32613068

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highly significantno p-value reported

Effect of chromatographic factors on responses The linear quadratic ANOVA data of response 1 ( Table 4 ) conforms that flow rate & column temperature (P-value < 0.0001) are showing highly significant effect on Resolution between DSA & C TZ, Chlorothiazide impurity and HCZ peak.

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