A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2- Metastatic Breast Cancer.

Int J Breast Cancer · 2020 · PMC7322582 · PMID 32637176

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an overall trendno p-value reported

However, NGS methodology was used more frequently in recent publications from both clinical and molecular trials, suggesting an overall trend towards the newer sequencing method.

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an increasing trendno p-value reported

There is an increasing trend towards conducting clinical trials that test for the presence of genetic mutations up front (at initial diagnosis), yet this typically requires fresh tissue biopsies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.