In linear mixed models adjusted for kinship, age, sex, and APOE genotype, the variants located in SLC9A3R1 (rs41282067), ITIH2 (rs143731868), and RHBDD2 (rs190871206) remained significantly associated with LOAD ( p ≤ 0.005 adjusted for multiple testing, table 2 ), and the variant in CDH23 (rs56013867) was close to significance.
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Synonymous variants associated with Alzheimer disease in multiplex families.
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