marginal significanceP < 0.001
When stratified by the region, there was a marginal significance between high pretreatment NLR and worse OS in the region of Asia (HR = 4.05, 95% CI 2.25–7.31; P < 0.001) and the regions of Europe and America (HR = 2.67, 95% CI 1.88–3.79, P < 0.001).