Programmed switch in the mitochondrial degradation pathways during human retinal ganglion cell differentiation from stem cells is critical for RGC survival.

Conclusion A switch from the ubiquitin proteasome system to the endo-lysosomal pathway for mitochondrial degradation and cell survival during RGC differentiation is potentially highly significant as it could reflect a general shift in the homeostasis of other proteins and organelles as well.

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