End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression.

Redox Biol · 2020 · PMC7327976 · PMID 32179051

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may be significantno p-value reported

These results suggest that the signaling pathway “Role of Cytokines in Mediating Communication between Immune Cells” may be significant in ESRD progression.

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highly significantno p-value reported

This is the first time for us to understand that in addition to uremic toxins identified, significant secretomic changes may play highly significant roles in driving ESRD pathogenesis.

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