highly significantP = 0.0043
This potential effect was highly significant in both validation cohorts (JAAMSR, P = 0.0043, adjusted hazard ratio 0.51, 95% CI 0.32–0.81; SPH, P = 0.018, adjusted hazard ratio 0.76, 95% CI 0.61–0.95) (Additional file 4 : Figure S3b-c).