Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs^-/- mice and thrombosis-prone CBS^-/- humans.

The top five highly significant pathways affected by both mouse Cbs deficiency and human CBS deficiency were Acute Phase Response Signaling (− log[ p -value] = 25.9 [humans] and 33.5 [mice]), LXR/RXR Activation (− log[ p -value] = 30.8 [humans] and 31.4 [mice]), FXR/RXR Activation (− log[ p -value] = 30.5 [humans] and 30.0 [mice]), Coagulation System, and Complement System (Fig. 4 B).

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