Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system.

CYP3A4-mediated triazole-release might not be significant for voriconazole due to the reduced order of the placement usages 14 , 18 ) ; the primary order observed experimentally is the N -oxide formation, followed by C -oxidation of the fluoropyrimidine and fluoropyrimidine N -oxide, methyl oxidation and triazole release in the decrease order 31 ) . 3.2 Placements of Myclobutanil, Hexaconazole and Propiconazole Myclobutanil is used as racemate and oxidized in a stereoselective manner in the body 32 , 33 ) .

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