Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice.

The difference between groups was highly significant ( p < 0.0001) (Fig. 4 a).

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For the other cytokines examined, there was a slight trend in the same direction with higher levels in treated animals, except for RANKL, however none showed significant difference (Table 1 ).

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