In the case of the KAHRP, which is located in knobs formed in trophozoite-infected erythrocytes, it may be significant that the protein was only found to be ubiquitylated in schizonts despite the fact that the gene is transcribed from the ring stage [ 36 ].
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Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development.
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