Interestingly, we observed an extremely significant increase of mean CD24 expression in IDH-mutant glioma of GSE16011 ; the mean z -scores of CD24 transcript in IDH-wildtype and IDH-mutant samples were −0.2425 and 0.4122, respectively ( p < 0.0001, 95% CI = 0.4011 to 0.9082), with a similar finding in TCGA-LGG: −0.2264 and 0.05148 ( p = 0.0021, 95% CI = 0.1017 to 0.4541) ( Fig. 2 A, B).
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The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma.
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