Rates of Potentially Inappropriate Dosing of Direct-Acting Oral Anticoagulants and Associations With Geriatric Conditions Among Older Patients With Atrial Fibrillation: The SAGE-AF Study.

There may be significant variations between the two. 29 Previous studies have shown higher stroke risk with underdosing and elevated bleeding risk with inappropriate overdosing of DOACs; hence, adherence to guideline‐directed dosing is important nonetheless. 11 , 12 , 13 , 25 Second, drug‐drug interactions are numerous and can be cumbersome to apply, leading to variations in dosing.

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