5 , 66 Another microscopical finding frequently reported in canine heatstroke patients is the detection of high numbers of nucleated red blood cells (nRBCs) at blood smear evaluation, which is considered a highly significant risk factor for death. 74 This occurrence has been attributed to direct thermal bone marrow injury, as well as to endothelial damage and microvascular thrombosis associated with DIC, leading to lesions of blood–bone marrow barrier and subsequent premature release of nRBCs into the bloodstream. 1 ,
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