Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice.

If corrected for age, the NfL increase in ataxic SCA3 subjects remained highly significant in both cohort #1 ( F (1,147) = 406.54, P < 0.001; based on a linear model with the factors group, age and their interaction, R 2 = 0.82; Fig 1 C) and cohort #2 ( F (1,70) = 169.49, P < 0.001, R 2 = 0.79; Fig 1 D).

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This positive association was confirmed with a similar effect size ( r = 0.29) also when adjusting for baseline SARA score, showing a statistical trend in this relatively small subcohort ( P = 0.100, 2‐sided test).

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