Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.

The increases in insoluble Aβ42 and Aβ40 in CatD-KO relative to WT controls were highly significant at all ages, both in terms of pairwise comparisons between age-matched groups (Fig. 2 a, b) and when analyzed by ANOVA using a mixed-effects model ( p < 0.0001 for age, genotype, and age × genotype for both Aβ42 and Aβ40).

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