For noncarriers, the quadratic effect of age on MMSE (β=-0.002786, p<0.0001), memory (β=-0.001388, p<0.0001), language (β=-0.001536, p<0.0001), attention (β=-0.00061, p<0.0001), visuospatial (β=-0.00165, p<0.0001) and executive function (β=-000711, p<0.0001) with the best-fitting regression was highly significant ( Figure 1 ).
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<i>APOE</i> ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.
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