Association of gut microbiota composition and function with an aged rat model of senile osteoporosis using 16S rRNA and metagenomic sequencing analysis.

Apart from the relative abundance of those two major phyla, Proteobacteria also showed a decreasing trend in the OP group (6.91%, CON: 3.02%, q<0.01) ( Figure 3C ).

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Helicobacter was the bacterium most positively related with osteoporosis and showed an increasing trend.

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