<i>HLA-DPB1*03</i> as Risk Allele and <i>HLA-DPB1*04</i> as Protective Allele for Both Early- and Adult-Onset Multiple Sclerosis in a Hellenic Cohort.

Nowadays, it is perfectly clear that the HLA-DP*03 allele is associated with MS and epitope spreading in MS [ 17 , 22 ], and in this study, we observed the risk susceptibility of this allele in our Hellenic MS sample, at a highly significant level ( p < 0.009, Table 2 ).

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