Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells.

As expected, a highly significant downregulation of SF3B1 and SNRPD3 mRNA was observed in siSF3B1 and siSNRPD3 treated cells, respectively, confirming effective gene silencing ( Figure 1 a,b).

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