Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.

Analysis of breast cancer transcriptomes (METABRIC cohort) also evidenced a very good correlation between the expression of FOLR2 and those of genes of the “anti-inflammatory gene set”, which reached statistical significance in most cases ( Figure 2 C), and was highly significant for CD163 (Pearson: 0.72; p = 1.71 × 10 −308 ) and even CD68 (Pearson: 0.59; p = 1.25 × 10 −176 ), another widely used marker for macrophage identification ( Figure 2 C).

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