Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers.

The highly significant correlations found between Aβ 40 oligomer size and hydrophobicity in the presence of designed antibodies and trodusquemine indicate that these agents cause paired increases of both parameters ( Figure 7 ), resulting in no significant effect on the toxicity of the Aβ 40 oligomers ( Supplementary Table S1 ).

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