Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea.

Physiol Rep · 2020 · PMC7354088 · PMID 32652816

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may be significantno p-value reported

It may be significant that EGF is a component of the culture medium for human enteroids. 4 DISCUSSION In this study, we successfully confirmed our hypothesis that EGFr TKI‐induced diarrhea is likely mediated by the action of these agents on epithelial transport, barrier function, or both.

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