Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM<sub>PZQ</sub> by PZQ, enhanced Ca<sup>++</sup> influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes.

Parasitol Res · 2020 · PMC7366562 · PMID 32607709

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highly significantno p-value reported

The differences between the human GPCR targets and TRP channels and the schistosome TRP channel are due to the highly significant differences in EC 50 values.

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