Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.

Nucleic Acids Res · 2020 · PMC7367204 · PMID 32496538

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Either H2Bub1 loss or Cdk9 inhibition alone was associated with highly significant decreases in Pst2:RNAPII ratio affecting all genes, irrespective of absolute levels of RNAPII occupancy (and, we infer, expression levels), with the htb1-K119R mutation producing the larger diminution (Figure 5E ).

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