Human amnion mesenchymal stem cells restore spermatogenesis in mice with busulfan-induced testis toxicity by inhibiting apoptosis and oxidative stress.

In comparison with those of the BSF group, the CASPASE3 and CASPASE9 protein levels exhibited a decreasing trend in the BSF/hAMSC group (Fig. 4 e, f). hAMSCs repressed oxidative damage and augmented oxidative defense in Sertoli cells treated with busulfan Sperm DNA can be damaged by oxidative stress that exceeds normal physiological levels, which can result in male infertility [ 28 ]; thus, we hypothesized that the hAMSC-transplanted recovery of spermatogenesis function could be an underlying stimulus by resisting oxidative stress.

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