ALADDIN study: does assisted hatching of vitrified/warmed blastocysts improve live birth rate? Protocol for a multicentric randomised controlled trial.

10 14 15 Some initial meta-analyses evaluated the effect of AH of embryos on clinical outcomes, reporting a borderline significant improvement in clinical pregnancy while the live birth rate was still not proven to be increased by the procedure. 16 17 These data were supported by a recent meta-analysis of randomised controlled trials (RCT) which confirmed higher clinical pregnancy and implantation rates using AH on previously cryopreserved embryos but failed to demonstrate significant effects on live birth rates. 18 Unfortunately, the pool of included studies comprised a small sample size and focused on cleavage-stage embryos.

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