Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats.

However, an extremely significant age effect was observed in relation to both NgR (F 2,30 = 104.653; P <0.001) and p75 (F 2,30 = 22.782; P <0.001) protein levels in the prefrontal cortex of the treated rats.

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While there was no significant main effect of treatment on protein expression (F 1,30 = 0.255; P =0.617), there was a highly significant main effect of age on levels of Lingo-1 protein expression (F 2,30 = 25.247; P <0.001).

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In all three cases, there was an increase in protein expression in the adult PCP treated rats compared with the control group, despite the effect on TROY protein expression only being a minor increase of 7% ( P =0.011; Figure 2 ), and the effect on Myt1 protein expression only equating to a borderline significant increase of 14.5% ( P =0.056; Figure 2 ).

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