Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.

A trend towards significance was seen between the maximum lysis of target cells and the number of antibodies bound per cell at the antibody concentration leading to maximum lysis as well as between overall antibody binding and ADCC, defined by area under the curve (Fig. 6 c, d), suggesting that the level of antibody binding could be an important determining factor for the level of cell cytotoxicity [ 53 , 54 ].

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However, although a positive trend towards correlation was clear for each parameter tested, none reached statistical significance.

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