Alzheimer's amyloid-β and tau protein accumulation is associated with decreased expression of the LDL receptor-associated protein in human brain tissue.

Furthermore, the ability of RAP to bind Aβ and act independently of LRP1 is supported by previous animal studies showing RAP deficiency does not significantly affect the levels of LRP1 (Xu et al., 2008 ), suggesting that either a relatively modest change in LRP1 may be significant enough to cause changes in Aβ deposition or RAP possesses an ability to affect Aβ independently of LRP1 (Xu et al., 2008 ).

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The findings in the present study were of a nonsignificant trend toward reduced NeuN in the same tissue volumes measured from the AD group compared to controls.

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