The increased protein level of cCasp3 at the two time points and decreased expression of p21 on day 3 indicated that apoptosis was involved in the killing effect meditated by ABT263, although the p21 level displayed an increasing trend on day 10 ( Figure 5F ).
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Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis.
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